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KMID : 0191120090240020289
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Journal of Korean Medical Science
2009 Volume.24 No. 2 p.289 ~ p.295
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Effect of Iron-Chelator Deferiprone on the In Vitro Growth of Staphylococci
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Kim Choon-Mee
Shin Sung-Heui
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Abstract
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The standard iron-chelator deferoxamine is known to prevent the growth of coagulase-negative staphylococci (CoNS) which are major pathogens in iron-overloaded patients. However, we found that deferoxamine rather promotes the growth of coagulase-positive Staphylococcus aureus. Accordingly, we tested whether deferiprone, a new clinically-available iron-chelator, can prevent the growth of S. aureus strains as well as CoNS. Deferiprone did not at least promote the growth of all S. aureus strains (n=26) and CoNS (n=27) at relatively low doses; moreover, it could significantly inhibit the growth of all staphylococci on non-transferrin-bound-iron and the growth of all CoNS on transferrin-bound iron at relatively high doses. At the same doses, it did not at least promote the growth of all S. aureus strains on transferrin-bound-iron. These findings indicate that deferiprone can be useful to prevent staphylococcal infections, as well as to improve iron overload, in iron-overloaded patients.
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KEYWORD
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Staphylococcus, Iron, Deferoxamine, Deferiprone, Transferrin
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